Mattress Mould Removal, If you are having trouble getting rid of a mattress mould, there are a few things that you can do. First, make sure that the mould is actually on the mattress itself. If it is on the bed frame or box spring, then it will be difficult to remove. Secondly, use a mold removal product that is specifically designed for mattresses. This will help to break down the mould and make it easier to remove. Finally, use a vacuum cleaner with high-velocity settings to help remove the mould.