Lexapro and Wellbutrin, are both similar and different from each other. Lexapro is used to treat mental disorders such as depression or anxiety. It belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). This medication works by helping to restore the balance of a certain natural substance in the brain. On the other hand, Wellbutrin is used to treat major depressive disorder (MDD). It is an antidepressant medicine that works in the brain and nerves on the chemical messengers norepinephrine and dopamine. Both Lexapro and Wellbutrin are associated with weight loss and appetite suppression. These medications are considered effective treatment options for depression.