Enhancing patient comfort during endoscopic procedures is crucial for a positive experience and optimal outcomes. Skilled endoscopy nursing interventions, such as effective communication and personalized care, significantly alleviate patient anxiety and discomfort. Nurses can reduce patients' fears and promote relaxation by providing clear explanations about the procedure, offering reassurance, and implementing relaxation techniques. Additionally, maintaining a calm environment, using gentle handling techniques, and monitoring for pain or distress throughout the process are key strategies to improve comfort.