DNA methylation analysis can help researchers and professionals gain insight into gene regulation as well as identify potential biomarkers. DNA methylation tends to occur in a relatively wide range of genomic regions in both normal and disease conditions. However, the current understanding of DNA methylation is still pieced together from fragmented information obtained by short-read sequencing. Emerging third-generation sequencing technologies (PacBio SMRT and Nanopore sequencing) can directly detect DNA methylation modifications.
