OPANA tablets are used to help relieve moderate to severe pain. Opana ER is exclusively intended for patients with a valid prescription from doctors who are highly skilled in their field and have extensive experience in treating individuals with chronic pain. It is recommended to take this medication every 12 hours, either one hour before or one to two hours after a meal, as advised by your doctor. doctor's guidance when taking your prescribed dosages. Teenagers should consult their doctor for appropriate dosing. It is imperative not to discontinue or alter the prescribed dosage without consulting your doctor. Prolonged use of higher doses may lead to potential side effects.