The Best Medicine For Anxiety Disorders SSRIs and SNRIs such as citalopram Escitalopram, the fluoxetine (Prozac) Venlafaxine, citalopram, and duloxetine are the first-line treatments for anxiety disorders. Exercise and psychotherapy are important for those with anxiety. Certain doctors prescribe antihistamines, like hydroxyzine (Atarax or Vistaril). They wor...